CALIFORNIA CITY, Calif. — Pregnant individuals who contract Covid-19 face a higher risk of having a very preterm birth — as well as any preterm birth — as per a study led by researchers at UC San Francisco.
The findings of the study named “Covid-19 During Pregnancy Associated with Preterm Birth” were published in the journal “The Lancet Regional Health-Americas.”
The risk of very preterm birth, which occurs at less than 32 weeks of gestation, was 60 percent higher for people infected with Covid-19 at some point in their pregnancy, while the risk of giving birth at less than 37 weeks (all preterm births) was 40 percent higher in those with infection.
For those who also had hypertension, diabetes, and/or obesity, as well as Covid-19, the risk of preterm birth rose 160 percent.
“Preterm birth is associated with many challenging outcomes for pregnant people and babies, and very preterm births carry the highest risk of infant complications,” said Deborah Karasek, lead and corresponding author, Ph.D., assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences, and researcher with the California Preterm Birth Initiative at UC San Francisco.
“Our results point to the importance of preventative measures to reduce Covid-19 infection among pregnant people to prevent preterm birth, including vaccination.”
“Pregnant people may have concerns about vaccines and the health of their baby, so being able to have an open dialogue that values those concerns, describes evidence about safety, and conveys the risks posed by Covid-19 infection during pregnancy is critically important,” said Karasek.
The American College of Obstetricians and Gynecologists on July 30 issued updated guidance strongly recommending that all pregnant individuals get vaccinated against Covid-19.
Pregnant people are considered a high-risk population for Covid-19 infection. Yet, less than a quarter have received at least one dose of vaccine, as per the US Centers for Disease Control and Prevention.
The UC San Francisco study was the first of its kind large enough to identify the risks of Covid-19 by specific subtype of preterm birth and by race, ethnicity, and insurance status.
The study data reflected both existing disparities in preterm birth rates for Black, Indigenous, and other people of color compared to whites and the known outsized burden of the pandemic on communities of color.
Latinx, American Indian/Alaska Native, Native Hawaiian/Pacific Islander people, and public insurance had disproportionately higher Covid-19 rates during pregnancy.
While 47 percent of pregnant people in the study overall were Latinx, they represented 72 percent of the people with Covid-19 diagnoses.
“Given that the burden of Covid-19 is greater in these populations, as is the burden of preterm birth, it really points to the need for an equity approach,” said Karasek.
“With the surge in infections and increase in the Delta variant, we must think about pregnant people, especially Black and Brown populations, as the groups that need to be prioritized, with supportive policies to reduce exposure and stress, and increase access to care.”
The researchers analyzed live births between July 2020 and January 2021 documented by California Vital Statistics birth certificates.
Of the 240,157 recorded births, nearly 9,000, or 3.7 percent, indicating a Covid-19 diagnosis in pregnancy. The preterm birth rate among birthing people with a Covid-19 diagnosis was 11.8 percent compared with 8.7 percent among those without Covid-19.
The overall sample included 47.2 percent Latinx, 26.8 percent white, 4.9 percent Black, 13.2 percent Asian, 0.03 percent American Indian/Alaskan Native, 0.4 percent Hawaiian/Pacific Islander, and 7.3 percent identified as other, unknown, or two or more races.
40 percent of people in the study had public insurance when they gave birth, and 15.9 percent had hypertension, diabetes, obesity, or a combination of these.
Having comorbidities along with Covid-19 infection increased the risk of preterm birth. Individuals with hypertension, diabetes, and/or obesity, as well as a Covid-19 diagnosis, had a 160 percent higher chance of very preterm birth and a 100 percent higher risk of preterm birth compared to those without comorbidities or Covid-19.
“Researchers found that preterm birth rates didn’t vary by whether the births were spontaneous or medically indicated, which may indicate multiple pathways between Covid-19 diagnosis and preterm birth,” said Karasek.
Limitations of the study included that it couldn’t determine when during pregnancy the individuals contracted Covid-19 or how serious the infections were.
These are essential details for understanding the mechanisms by which Covid-19 affects preterm birth risk. Karasek said they are currently being studied at UC San Francisco and elsewhere.
(With inputs from ANI)
Edited by Vaibhav Pawar and Saptak Datta
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